Flubromazepam: A Comprehensive Overview for Research Applications

Product Name: Flubromazepam
Chemical Name: 7-Bromo-5-(2-fluorophenyl)-1,3-dihydro-2H-1,4-benzodiazepin-2-one
CAS Number: 2647-50-9
Molecular Formula: C₁₅H₁₀BrFN₂O
Molar Mass: 333.16 g/mol

Introduction: A Distinctive Benzodiazepine Derivative

Flubromazepam represents a significant compound within the class of benzodiazepine research chemicals, renowned for its unique pharmacokinetic profile. As a 1,4-benzodiazepine derivative, it is distinguished by the presence of a fluorine atom at the ortho position of the 5-phenyl ring and a bromine atom at the 7-position of the benzodiazepine ring system. These specific structural modifications are the key to its characteristic long duration of effects and high potency, making it a subject of considerable interest for advanced pharmacological research and laboratory analysis.

Key Characteristics and Research Properties

• Exceptionally Long Half-Life: Flubromazepam is most notable for its profoundly long elimination half-life, which is a subject of significant study. Preliminary data suggests a half-life exceeding 100 hours. This property indicates a very slow metabolic breakdown, resulting in a sustained presence in experimental models. Researchers must account for this extended duration in the design of their study timelines, as effects and metabolites may be detectable for several days.

• High Potency: This compound exhibits a high degree of potency. It is significantly more potent than its parent compound, Diazepam. This high efficacy means that extremely small masses are required to achieve a measurable effect in a laboratory setting, demanding precision and the use of advanced analytical equipment for proper handling and measurement.

• GABAergic Activity: Like classical benzodiazepines, Flubromazepam is understood to act as a positive allosteric modulator at the GABA-A receptor site in vitro. By enhancing the effect of the inhibitory neurotransmitter GABA, it potentiates the opening of chloride ion channels, leading to neuronal hyperpolarization and a subsequent reduction in central nervous system excitability. This mechanism is a cornerstone of research into GABAergic systems.

Intended Applications and Research Use

Flubromazepam is sold strictly as a chemical for scientific research and forensic analysis. It is not for human or veterinary consumption.

Its primary applications include, but are not limited to:

• Pharmacological Profiling: Studying the structure-activity relationships (SAR) of benzodiazepines, particularly the impact of halogen substitutions (fluorine and bromine) on receptor binding affinity, duration of action, and metabolic pathways.

• Metabolic Studies: Investigating the long-term metabolic pathways and identifying potential metabolites in various biological matrices due to its extended half-life.

• Analytical Reference Standard: Use as a high-purity standard in chromatography (HPLC, GC-MS) and spectrometry for the identification and quantification of benzodiazepines in research samples.

• Neurochemical Research: Exploring the effects of prolonged GABA receptor modulation on neuronal networks and communication in controlled laboratory environments.

Handling, Storage, and Safety Information

• Purity: >99% Pure

• Appearance: Fine white to off-white crystalline powder.

• Solubility: Soluble in organic solvents such as ethanol, methanol, and DMSO. Has limited solubility in water.

• Storage: Must be stored in a cool, dry, and dark environment. Ensure the container is tightly sealed to protect the compound from moisture and degradation.

• Handling: Researchers must exercise extreme caution. This material is intended for use by qualified professionals in a controlled laboratory setting. Personal protective equipment (PPE) including gloves, lab coats, and safety glasses should be worn at all times to prevent accidental exposure. Avoid inhaling dust or allowing contact with skin and eyes.

Disclaimer and Important Notice

WARNING: FLOBROMAZEPAM IS NOT INTENDED FOR HUMAN CONSUMPTION.
This product is sold for forensic and scientific research purposes only. It is not a drug, dietary supplement, or medicinal product. It does not possess approval from any regulatory body for human consumption. The safety profile of this substance for human use has not been established, and it may pose significant risks to health, including severe sedation, amnesia, dependence, and life-threatening interactions with other depressants.

By purchasing this product, the buyer acknowledges and agrees that they are a qualified researcher, at least 18 years of age, and that they understand the intended legal use and potential hazards associated with handling this chemical. The buyer is solely responsible for ensuring that their purchase and use of this product comply with all local, state, and federal laws and regulations governing their specific region and institution.

Ordering Information

We pride ourselves on providing the research community with the highest quality chemicals. Every batch of our Flubromazepam is subjected to rigorous in-house analytical testing to ensure identity, purity, and consistency. It is supplied in a secure, labeled container to guarantee integrity during transit.