Sevoflurane (CAS 28523-86-6) – The Premium Inhalation Anesthetic Agent

Sevoflurane (CAS 28523-86-6) is a modern, non-flammable, halogenated ether inhalation anesthetic renowned for its exceptional clinical profile and favorable safety characteristics. Representing the gold standard in modern volatile anesthesia, it is extensively utilized in the induction and maintenance of general anesthesia for both inpatient and outpatient surgical procedures across all age groups, from pediatric to geriatric patients.

Manufactured under strict cGMP (current Good Manufacturing Practices) guidelines, our Sevoflurane is supplied to the highest degree of chemical purity and consistency, ensuring reliable performance and safety in the most critical clinical settings.

Key Features & Advantages:

• High Purity Grade: Meets and exceeds all pharmacopeial standards (USP, Ph. Eur., JP) for identity, assay, and impurities, ensuring patient safety and product efficacy.

• Excellent Safety Profile: Offers rapid induction and emergence with a low incidence of airway irritation, making it ideal for smooth mask inductions, especially in pediatric patients.

• Precise Control & Rapid Titration: Low blood-gas solubility coefficient (0.65) allows for quick adjustments in anesthetic depth and faster patient recovery, enhancing operating room efficiency.

• Minimal Metabolism: Undergoes significantly less metabolism in the body compared to other agents, reducing the potential for hepatotoxic effects.

• Superior Stability: Packaged in sealed, tamper-evident containers under nitrogen atmosphere to ensure chemical integrity and prevent degradation.

Chemical Specifications:

• Chemical Name: Sevoflurane

• Synonyms: 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane; Fluoromethyl hexafluoroisopropyl ether

• CAS Number: 28523-86-6

• Molecular Formula: C₄H₃F₇O

• Molecular Weight: 200.06 g/mol

• Appearance: Clear, colorless liquid

• Odor: Characteristic, mild, ethereal odor (non-pungent)

• Solubility: Practically insoluble in water; miscible with ethanol and diethyl ether.

• Boiling Point: Approximately 58.6°C at 101.3 kPa

• Density: ~1.51 g/cm³ at 20°C

Mechanism of Action:

Sevoflurane exerts its general anesthetic effect by potentiating the activity of the GABAₐ receptor and glycine receptors in the central nervous system, leading to neuronal hyperpolarization and inhibition of synaptic transmission. It may also antagonize the NMDA receptor. This combined action results in the reversible loss of consciousness, amnesia, analgesia, and inhibition of autonomic reflexes.

Applications & Intended Use:

This product is an Active Pharmaceutical Ingredient (API) and is intended exclusively for pharmaceutical manufacturing use. It is the critical raw material used in the final formulation and filling of inhalation anesthetics. Its primary applications include:

• Formulation of Finished Dosage Forms: Used by licensed pharmaceutical companies to produce the final medicinal product packaged in specialized vaporizer bottles.

• Hospital & Clinical Use: The finished drug product is administered via calibrated vaporizers integrated into anesthesia delivery systems for the induction and maintenance of general anesthesia.

• Research & Development: Utilized in preclinical and clinical research to study anesthetic mechanisms, develop new delivery systems, and compare efficacy and safety profiles.

Packaging & Storage:

To preserve its exceptional quality and stability, our Sevoflurane is packaged in:

• Amber Glass Bottles or HDPE Plastic Bottles to protect from light.

• Sealed with appropriate closures to prevent moisture ingress and evaporation.

• Optionally available under an inert nitrogen headspace to minimize oxidative degradation.

• Standard packaging sizes range from 100g to 5kg, with custom packaging available upon request.

Storage Conditions: Store in a cool, well-ventilated place, protected from light at controlled room temperature (15-25°C or as specified on the Certificate of Analysis). Keep the container tightly closed and sealed.

Quality & Compliance:

Every batch of our Sevoflurane is accompanied by a comprehensive Certificate of Analysis (CoA) that provides full traceability and verification of its quality. Our manufacturing facilities are rigorously audited to ensure compliance with international regulatory requirements.

Disclaimer: This product is intended for industrial and pharmaceutical manufacturing use only. It is not for direct human or veterinary use. The handling and formulation of this API should only be performed by qualified professionals in appropriately equipped facilities with a thorough understanding of safe pharmaceutical practices. Always refer to the Safety Data Sheet (SDS) before handling.

Choose our Sevoflurane API for your critical anesthesia formulations and experience the reliability, purity, and performance that modern medicine demands.